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Schizophrenia Treatment and Antipsychotic Management

Select and manage antipsychotic therapy for schizophrenia, including clozapine initiation and long-acting injectable transitions, with confidence.

What this track covers

This track covers the clinical decision points in schizophrenia care: recognizing psychotic symptoms against DSM-5 criteria, choosing among first- and second-generation antipsychotics, and managing treatment-resistant cases with clozapine. It also addresses long-acting injectable selection and transition planning, alongside the role of psychosocial support in sustaining remission.

What you will practice

  • Differentiate schizophrenia from other causes of psychosis using DSM-5 criteria
  • Compare antipsychotic side-effect profiles when choosing an initial agent
  • Identify criteria for treatment resistance that warrant a clozapine trial
  • Plan a monitoring schedule for a patient starting clozapine
  • Decide when and how to transition a patient to a long-acting injectable

Simulator scenario

A patient with persistent positive symptoms despite two adequate antipsychotic trials presents for evaluation of next treatment steps, including a discussion of clozapine.

Board question topics

  • DSM-5 criteria for schizophrenia and differential diagnosis of psychosis
  • Antipsychotic selection and side-effect management
  • Clozapine monitoring requirements
  • Long-acting injectable candidacy and transition planning

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