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Ketamine and Esketamine for Depression

You'll be able to evaluate a patient for treatment-resistant depression, select an appropriate ketamine or esketamine pathway, and monitor safely through and after administration.

What this track covers

This track covers IV ketamine and intranasal esketamine for treatment-resistant depression, from mechanism and patient selection through administration safety and post-treatment monitoring. It also addresses REMS requirements for esketamine and how a monitoring workflow fits into ongoing patient care.

What you will practice

  • Screen a patient for treatment-resistant depression and identify contraindications
  • Differentiate when IV ketamine versus intranasal esketamine may be considered
  • Set up a monitoring plan for dissociative effects and vital signs during administration
  • Recognize and respond to adverse events during or after a session
  • Apply esketamine REMS monitoring requirements to a clinic workflow

Simulator scenario

A patient with treatment-resistant depression presents for an initial esketamine session and develops dissociative symptoms and a blood pressure change during the monitored observation period.

Board question topics

  • Patient selection criteria for treatment-resistant depression
  • REMS requirements for esketamine administration
  • Monitoring parameters during ketamine/esketamine sessions
  • Recognizing and managing adverse events post-administration

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