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Cancer Genomics and Tumor Profiling

Read a comprehensive genomic profiling report and translate driver alterations into a reasoned treatment discussion.

What this track covers

This track covers how somatic mutations arise and drive tumor behavior, how to interpret next-generation sequencing reports, and how genomic findings inform targeted therapy selection. It's built for clinicians who review molecular pathology results or participate in tumor board discussions and want to move from recognizing terms to reasoning through cases.

What you will practice

  • Distinguish driver mutations from passenger mutations in an NGS report
  • Identify actionable alterations and match them to relevant therapy classes
  • Interpret variant allele frequency and tumor mutational burden values in context
  • Recognize resistance mutations that emerge after targeted therapy
  • Structure a tumor board summary from a molecular profiling report

Simulator scenario

A virtual patient with newly diagnosed metastatic non-small cell lung cancer presents with a comprehensive genomic profiling report, and the clinician must identify the actionable alteration and reason through first-line targeted therapy options.

Board question topics

  • Driver vs. passenger mutation identification
  • NGS report interpretation basics
  • Targeted therapy selection based on molecular markers
  • Mechanisms of acquired resistance

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