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Chemotherapy Drug Classes and Toxicity

You'll be able to classify chemotherapy agents by mechanism, anticipate their characteristic toxicities, and select appropriate supportive care and dose modifications.

What this track covers

This track covers the major chemotherapy drug classes, including alkylating agents, antimetabolites, antimicrotubule agents, topoisomerase inhibitors, and targeted therapies, along with the cell-cycle mechanisms behind their effects. It also addresses toxicity grading, dose modification triggers, supportive care strategies, safe handling practices, and the basics of checkpoint inhibitor and CAR-T related immune adverse events.

What you will practice

  • Match a chemotherapy agent to its drug class and mechanism of action
  • Grade a reported adverse event and decide whether it warrants dose modification or hold
  • Choose an antiemetic strategy based on emetogenic risk category
  • Recognize early signs of an immune-related adverse event versus a standard cytotoxic toxicity
  • Apply infection prophylaxis and growth factor support decisions for at-risk patients

Simulator scenario

A patient on a multi-agent chemotherapy regimen presents with new symptoms during a treatment cycle, and the clinician must grade the toxicity, decide on supportive care, and determine whether to proceed, modify, or hold the next dose.

Board question topics

  • Chemotherapy drug class mechanisms
  • Toxicity grading and dose modification thresholds
  • Antiemetic and growth factor supportive care
  • Immune-related adverse events from checkpoint inhibitors

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