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Psoriasis Systemic and Biologic Therapy

Work through this track to select, sequence, and monitor systemic and biologic therapy for moderate-to-severe psoriasis, including comorbid psoriatic arthritis.

What this track covers

This track covers psoriasis pathophysiology and phenotypes, topical and traditional systemic options, and the major biologic classes (TNF, IL-17, IL-23, IL-12/23 inhibitors) used when disease is moderate to severe. It also addresses pre-treatment screening, comorbidity management including psoriatic arthritis and cardiovascular risk, and considerations for pregnancy, pediatric, and elderly patients.

What you will practice

  • Distinguishing plaque, guttate, pustular, and erythrodermic phenotypes
  • Matching disease severity and comorbidities to a therapy class
  • Sequencing workup before starting a systemic or biologic agent
  • Recognizing screening and monitoring needs specific to each drug class
  • Identifying red flags for psoriatic arthritis and coordinating referral

Simulator scenario

A patient with longstanding plaque psoriasis presents with new joint pain and morning stiffness, requiring the clinician to assess for psoriatic arthritis and reconsider the treatment plan.

Board question topics

  • Mechanism of action across biologic classes
  • Pre-treatment screening requirements
  • Psoriatic arthritis recognition and workup
  • Special population treatment considerations

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